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KMID : 1037120130310010036
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The World Journal of Men′s Health
2013 Volume.31 No. 1 p.36 ~ p.46
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Clinical Significance of Wnt/?-Catenin Signalling and Androgen Receptor Expression in Prostate Cancer
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Jung Soo-Jin
Oh Sang-Taek
Lee Geun-Taek
Chung Jae-Il
Min Kweon-Sik
Yoon Jang-Ho
Kim Wan-Suk
Kang Dong-Il
Kim Issac-Yi
Ryu Dong-Soo
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Abstract
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Purpose: To investigate the relationships among the Wnt/?-catenin pathway, androgen receptor (AR), and clinicopathological factors in hormone-naive prostate cancer.
Materials and Methods: This study was conducted with132 cases of hormone-naive prostate cancer treated by prostatectomy and prostate needle biopsy. An immunohistochemical study using antibodies against ?-catenin, matrix metalloproteinase-7 (MMP-7), and the AR was performed. For the in vitro study, PC-3, LNCaP, 22Rv1, and DU145 cell lines were used.
Results: The clinical or pathological stage ware a localized cancer in 36 patients (27.3%), locally advanced cancer in 31 (23.5%), and metastatic cancer in 65 (49.2%). We detected increased ?-catenin, AR, and MMP-7 expression with a high Gleason grade, disease progression, and increasing serum prostate-specific antigen (PSA) levels (p＜0.01). In Spearman’s rank correlations, the expression of cytoplasmic ?-catenin, MMP-7, and the AR were found to be significantly positively correlated. In addition, the expression of ?-catenin, MMP-7, and the AR were significantly correlated with clinicopathological variables indicative of a poor prognosis. Forty-nine patients with primary androgen deprivation had short response durations from hormone therapy to PSA progression with elevated MMP-7 expression on the Kaplan-Meier curve (p=0.0036).
Conclusions: These data show that an activated Wnt/?-catenin pathway and AR expression in prostate cancer are correlated with metastasis and aggressiveness. In addition, the expression of MMP-7 protein, a target of the Wnt/?-catenin pathway, is associated with PSA progression in prostate cancer patients undergoing primary hormone therapy.
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KEYWORD
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Prostate neoplasms, Beta catenin, Matrix metalloproteinases, Receptors, androgen, Prognosis
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